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phenobarbital will decrease the extent or impact of buprenorphine, prolonged-performing injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Clients who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to be sure

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